Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 260254Generated: October 26, 2026

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-

https://huagongshe.com/reaction/260254

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
ReactantN-HydroxysuccinimideHCID 80170—
ReactantCotinineHCID 854019—
Product2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-HCID 414—

Reaction Steps

Hydroxycotinine hemisuccinate succinic ester was prepared by adding to 1 ml of cotinine hemisuccinate 14 mg of N-hydroxysuccinimide (Sigma) and 23 mg of 1-ethyl-3-(dimethylaminopropyl) carbodiimide (Sigma) and incubating at room temperature for 3 ]]ours.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05527686
Source datasetuspto-grants-1996_06
ORD IDord-fa2142ef38c543bea86ec988990e1d14
Source noteuspto-grants-1996_06