Sodium Cyanide → HCID 15293162, compound

Participants

Reaction Steps

A 2.0 g quantity of the compound obtained in Example 23 was dissolved in a mixture of 5 ml of ethanol and 0.6 ml of water. After addition of 0.48 g of sodium cyanide with stirring at room temperature, the reaction mixture was refluxed with heating for 12 hours. After addition of 20 ml of water, the reaction mixture was extracted with ethyl acetate. The ethyl acetate layer was washed serially with 20 ml of water and 20 ml of brine and dried over Glauber's salt. The solvent was distilled off under reduced pressure and the residue was subjected to silica gel column chromatography (eluent: chloroform:ethyl acetate=1:1). The resulting crude crystals were recrystallized from dichloromethane-n-hexane to provide 1.0 g of the title compound as colorless crystals. Table 1 shows the structure and physical property of the compound obtained.

Provenance & Evidence