HCID 22861997, compound → HCID 22861998, compound

HRID 260290Notes

Reaction equation

HRID 260290 reaction equation
[C:1]([NH:5][C:6]([C@@H:8]1[CH2:13][N:12]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10][N:9]1NC(CC1C=CC=CC=1)=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd].CO>[C:1]([NH:5][C:6]([C@@H:8]1[CH2:13][N:12]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10][NH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 22861997HCID 22861997, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22861998HCID 22861998, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 1.20g (2.86 mmol) of N-t-butyl-4-(1,1-dimethylethoxycarbonylamino)-1-(phenylmethylcarbonylamino)piperazine-2(S)-carboxamide and 1.1g (0.086 mmol) of 10% Pd/C was added 15 mL of methanol. The vessel was charged with hydrogen and the reaction stirred for 2 hours, filtered through celite and washed with ethanol. The solvents were removed in vacuo to provide the title product as a foam.

Workup

  1. filtrationfiltered through celite
  2. washwashed with ethanol
  3. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-432663eb189a4f03a91a070182312c18
Source dataset
uspto-grants-1996_06
Patent number
US05527799

Reaction notes

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