HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4S)-4-Acetylthio-1-allyloxycarbonyl-2-carboxypyrrolidine → (2S,4S)-4-acetylthio-1-allyloxycarbonyl-2-(3(allyloxycarbonylmethoxymethyl)phenylcarbamoyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4S)-4-Acetylthio-1-allyloxycarbonyl-2-carboxypyrrolidine | HCID 15299255 | — |
| Reactant | Allyl 3-aminobenzyloxyacetate | HCID 22401146 | — |
| Reactant | Allyl 3-aminophenoxyacetate | HCID 22401151 | — |
| Product | (2S,4S)-4-acetylthio-1-allyloxycarbonyl-2-(3(allyloxycarbonylmethoxymethyl)phenylcarbamoyl)pyrrolidine | HCID 57141411 | — |
Reaction Steps
Allyl 3-aminobenzyloxyacetate was condensed with (2S,4S)-4-acetylthio-1-allyloxycarbonyl-2-carboxypyrrolidine by the method described in example 3 for allyl 3-aminophenoxyacetate, except that crude product was purified by chromatography on silica, using a gradient from di-chloromethane to dichloromethane/diethyl ether (85:15), to give (2S,4S)-4-acetylthio-1-allyloxycarbonyl-2-(3(allyloxycarbonylmethoxymethyl)phenylcarbamoyl)pyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527791 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-362d96d2bdfb4c769a021b97d5f960d9 |
| Source note | uspto-grants-1996_06 |