Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-Phenyllactic acid, (S)- | HCID 444718 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 11830633 | HCID 11830633 | 94.1% |
Reaction Steps
Mix (S)-3-phenyllactic acid (11.17 g, 67.2 mmol) and sulfuric acid (0.3 mL of a 10% solution in acetic acid). Add acetic anhydride (6.34 mL, 67.2 mmol) over 10 minutes. Warm to 90° C. with stirring for 45 minutes. Allow to cool, pour into diethyl ether and wash with water three times. Separate the organic phase, dry (MgSO4) and concentrate in vacuo to yield 13.16 g (94%) (S)-3-phenyl-2-acetyloxypropionic acid as a white oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05527795 |
|---|
| Source dataset | uspto-grants-1996_06 |
|---|
| ORD ID | ord-96c719ad27d84f89a2a1c2049bf2976c |
|---|
| Source note | uspto-grants-1996_06 |
|---|
