HCID 54463660, compound → HCID 10656658, compound

HRID 260356Notes

Reaction equation

HRID 260356 reaction equation
[N:1]12[CH2:16][CH:5]([C:6](=[C:8]([C:14]#[N:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:7]1)[CH2:4][CH2:3][CH2:2]2.[H][H]>[Pd].C(O)C>[N:1]12[CH2:16][CH:5]([CH:6]([CH:8]([C:14]#[N:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:7]1)[CH2:4][CH2:3][CH2:2]2

Participants

5

Reactant 2

HCID 54463660HCID 54463660, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 10656658HCID 10656658, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl (1-azabicyclo[3.2.1]octan-6-ylidene)cyanoacetate (41 g, 0.19 mol) in abs. ethanol (500 ml) was treated with 10% palladium on carbon (5 g) and hydrogen in a Parr shaker at 30 psi for 5 h. Filtration and evaporation gave the title compound in 36 g yield.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-191a0c02370d4973b91caff3da13b213
Source dataset
uspto-grants-1996_06
Patent number
US05527813

Reaction notes

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