Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Flurbiprofen | HCID 3394 | — |
| Product | Ibuprofen, (+-)- | HCID 3672 | — |
Reaction Steps
Three grams of flurbiprofen and 30 g of poloxamer 237 were heated at 110° C. for 10 minutes to obtain a liquified mixture and cooled to 60° C. Into this mixture, 5 g of polyethylene glycol 300, 10 g of ethanol and 52 g of pH 4 buffer solution were added at 60° C. to obtain an ibuprofen gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05527832 |
|---|
| Source dataset | uspto-grants-1996_06 |
|---|
| ORD ID | ord-b0ad4fad120e4b30b6d002e81134c3db |
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| Source note | uspto-grants-1996_06 |
|---|
