Phenol → 5-Fluoro-3-(3-hydroxypent-3-yl)phenol

HRID 260422Notes

Reaction equation

HRID 260422 reaction equation
[C:1]1(O)C=CC=CC=1.[F:8][C:9]1[CH:10]=[C:11]([C:23]([OH:31])([C:26]2SC=CN=2)[CH2:24][CH3:25])[CH:12]=[C:13]([O:15]CC2C=CC=CC=2)[CH:14]=1>>[F:8][C:9]1[CH:10]=[C:11]([C:23]([OH:31])([CH2:24][CH3:25])[CH2:26][CH3:1])[CH:12]=[C:13]([OH:15])[CH:14]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 199096325-fluoro-3-[1-hydroxy-1-(thiazol-2-yl)propyl](O-benzyl)phenol

Product 1

HCID 153426805-Fluoro-3-(3-hydroxypent-3-yl)phenol

Procedure

Following the procedure described for Phenol 1, Step 3, but substituting 5-fluoro-3-(3-hydroxypent-3-yl)[O-(3,4-dimethoxybenzyl)]phenol from Step 2 for 5-fluoro-3-[1-hydroxy-1-(thiazol-2-yl)propyl](O-benzyl)phenol the title compound was obtained as a solid.

Sources & evidence

ORD record
ord-f872e601086e41df906b6e26ab075802
Source dataset
uspto-grants-1996_06
Patent number
US05527827

Reaction notes

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