Phenol → 3-[1-Hydroxy-1-(pyridin-2-yl)propyl]phenol

HRID 260425Notes

Reaction equation

HRID 260425 reaction equation
[C:1]1(O)C=CC=C[CH:2]=1.[OH:8][C:9]([C:17]1[CH:18]=[C:19]([O:23][Si](C(C)(C)C)(C)C)[CH:20]=[CH:21][CH:22]=1)([C:12]1S[CH:14]=[CH:15][N:16]=1)[CH2:10][CH3:11]>>[OH:8][C:9]([C:17]1[CH:18]=[C:19]([OH:23])[CH:20]=[CH:21][CH:22]=1)([C:12]1[CH:2]=[CH:1][CH:14]=[CH:15][N:16]=1)[CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 996PhenolHCID 150499543-[1-hydroxy-1-(thiazol-2-yl)propyl)(O-tert-butyldimethylsilyl)phenol

Product 1

HCID 194269833-[1-Hydroxy-1-(pyridin-2-yl)propyl]phenol

Procedure

Following the procedure described for Phenol 6, Step 3 but substituting 3-[1-hydroxy-1-(pyridin-2-yl)propyl](O-tert-butyldiphenylsilyl)phenol from Step 4 for 3-[1-hydroxy-1-(thiazol-2-yl)propyl](O-tert-butyldimethylsilyl)phenol, the title compound was obtained.

Sources & evidence

ORD record
ord-0f27b0122aeb437a94d2d86703037b60
Source dataset
uspto-grants-1996_06
Patent number
US05527827

Reaction notes

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