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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 260429Generated: October 30, 2026

5-Fluoro-3-(hexafluoro-2-hydroxyprop-2-yl)-1-(2-trimethylsilylethylthio)benzene → 5-Fluoro-3-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]thiophenol

https://huagongshe.com/reaction/260429

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Fluoro-3-(hexafluoro-2-hydroxyprop-2-yl)-1-(2-trimethylsilylethylthio)benzeneHCID 19426956—
Reactant1,3-Difluoro-5-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]benzeneHCID 19426986—
Product5-Fluoro-3-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]thiophenolHCID 19426992—

Reaction Steps

Following the procedure described for Thiophenol 1, Step 3, but substituting the 5-fluoro-3-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]-1-(2-trimethylsilylethylthio)benzene from Step 4 for 5-fluoro-3-(hexafluoro-2-hydroxyprop-2-yl)-1-(2-trimethylsilylethylthio)benzene as starting material, the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05527827
Source datasetuspto-grants-1996_06
ORD IDord-0469d44c97114ebfbc235a9e6c872750
Source noteuspto-grants-1996_06