HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → 5-Fluoro-3-(1-hydroxy-1-phenylpropyl)thiophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | 1,3-Difluoro-5-(1-phenyl-1-trimethylsilyloxy-2,2,2-trifluoroethyl)benzene | HCID 19426936 | — |
| Reactant | (3,5-Difluorophenyl)(thiazol-2-yl)methanone | HCID 19426944 | — |
| Reactant | HCID 178418255 | HCID 178418255 | — |
| Reactant | HCID 178418507 | HCID 178418507 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Fluoro-3-(1-hydroxy-1-phenylpropyl)thiophenol | HCID 19426982 | — |
Reaction Steps
Following the procedure described for Thiophenol 2, Step 3 and Thiophenol 1, Steps 2 and 3 but substituting 3,5-difluoropropiophenone (Lancaster) for (3,5-difluorophenyl)(thiazol-2-yl)methanone and phenylmagnesium bromide in THF (Aldrich) for vinylmagnesium bromide as starting material the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527827 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-11dab32254094a6caa5c35d76e3c749e |
| Source note | uspto-grants-1996_06 |