HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 7-Bromomethyl-4-(3-furyl)coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-(3-Furyl)-7-methylcoumarin | HCID 23370190 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 7-Bromomethyl-4-(3-furyl)coumarin | HCID 15780564 | 42.2% |
Reaction Steps
To a solution of 4-(furan-3-yl)-7-methylcoumarin (1.2 g, 5.3 mmol) in CCl4 (40 mL) was added NBS (1 g, 5.8 mmol) followed by AIBN (87 mg, 0.53 mmol). The resulting mixture was refluxed for 4 h, then cooled to r.t. filtered and evaporated. Purification by chromatrography on silica gel gave 682 mg (42%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527827 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-14da0efd0a7047c2a16605ed15a28977 |
| Source note | uspto-grants-1996_06 |