HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Furyl)-7-mercaptocoumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 7-(2-Trimethylsilylethylthio)-4-(3-furyl)coumarin | HCID 23370244 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(3-Furyl)-7-mercaptocoumarin | HCID 23370194 | 90.8% |
Reaction Steps
The coumarin from Step 1 (963 mg) was dissolved in DMF (25 mL) and to this solution there was added n-Bu4NF (1M) in THF (8.4 mL). The mixture was stirred at r.t. for 2 h, poured onto 1N aqueous HCl (50 mL), diluted with H2O (50mL) and filtered to afford the title compound (620 mg) as a tan. solid. m.p.: 167°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527827 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-0f4377e8640246c0b12476d1fd85b086 |
| Source note | uspto-grants-1996_06 |