HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-Methoxy-N-methyl-5-chloro-3-phenylthioindole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 178526153 | HCID 178526153 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-Methoxy-N-methyl-5-chloro-3-phenylthioindole-2-carboxamide | HCID 86749576 | — |
Reaction Steps
The title compound was prepared from 5-chloro-3-phenylthioindole-2-carboxylic acid (1.0 g, 3.30 mmol)) N,O-dimethylhydroxylamine hydrochloride (0.64 g, 6.6 mmol), triethylamine (1.0 mL, 7 mmol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorphosphate (1.64 g, 3.6 mmol) in dimethylformamide according to the general procedure described in Example 1 for the preparation of N-(3-pyridylmethyl)-5-chloro-3-phenylthio-2-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527819 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-93bdeeb84edc4e0fafb32025608889b1 |
| Source note | uspto-grants-1996_06 |