Sodium Hydroxide → HCID 67731713, compound

HRID 260487Notes

Reaction equation

[C:1]([C:6]1[N:7](S(C2C=CC=CC=2)(=O)=O)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([Cl:15])=[CH:10][CH:9]=2)([O:3]CC)=[O:2].C[C:26]1[CH:27]=[C:28]([S:32]([NH2:35])(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1.[OH-].[Na+].CO.[CH2:40]1COCC1>>[Cl:15][C:11]1[C:12]([NH:35][S:32]([C:28]2[CH:27]=[CH:26][CH:31]=[CH:30][CH:29]=2)(=[O:34])=[O:33])=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:1]([OH:3])=[O:2])=[C:14]2[CH3:40]

Participants

Reactant 3

HCID 14798Sodium Hydroxide

HCID 21899815MeOH tetrahydrofuran

HCID 67731710HCID 67731710, compound

Product 1

HCID 67731713HCID 67731713, compound

Procedure

In the manner outlined in Example 69, Step B, 2-carboethoxy-5-chloro-1-phenylsulfonylindole-3-methyl(phenyl)sulfonamide (0.39 g, 0.75 mmol) was hydrolysed in 2:1:1 10% sodium hydroxide solution/methanol/THF (20 ml, 14 h at RT (room temperature) followed by 5 min at reflux), to give the title compound (from ethyl acetate);

Sources & evidence

ORD record: ord-ff5ad879bed14538b8e6645ea3bea65b
Source dataset: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05527819

Reaction notes

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