1H-Imidazole-1-propanamine → N-[3-(imidazol-1-yl)propyl]-3-phenylsulfonyl-5-chloroindole-2-carboxamide

HRID 260490Notes

Reaction equation

HRID 260490 reaction equation
[C:1]1([S:7]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([Cl:19])[CH:17]=3)[NH:12][C:11]=2[C:20]([OH:22])=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:23][CH2:24][CH2:25][CH2:26][N:27]1[CH:31]=[CH:30][N:29]=[CH:28]1>>[N:27]1([CH2:26][CH2:25][CH2:24][NH:23][C:20]([C:11]2[NH:12][C:13]3[C:18]([C:10]=2[S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:8])=[O:9])=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)=[O:22])[CH:31]=[CH:30][N:29]=[CH:28]1

Participants

3

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 158135163-Phenylsulfonyl-5-chloroindole-2-carboxylic acid

Product 1

HCID 22401493N-[3-(imidazol-1-yl)propyl]-3-phenylsulfonyl-5-chloroindole-2-carboxamide

Procedure

Reaction of the 3-phenylsulfonyl-5-chloroindole-2-carboxylic acid with 1-(3-aminopropyl)imidazole under the conditions of Example 37 gave the title compound, mp 216°-217.5° C.

Sources & evidence

ORD record
ord-a4198a2ca4dd4acfbad0aadbb2424b87
Source dataset
uspto-grants-1996_06
Patent number
US05527819

Reaction notes

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