2-Aminoisonicotinonitrile → 4-(Aminomethyl)pyridin-2-amine

HRID 260493Notes

Reaction equation

HRID 260493 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.NC1C(CN)=CC=CN=1>>[NH2:1][C:2]1[CH:7]=[C:6]([CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 70155242-AminoisonicotinonitrileHCID 123582333-(Aminomethyl)pyridin-2-amine

Product 1

HCID 341768864-(Aminomethyl)pyridin-2-amine

Procedure

2-Aminopyridine-4-carbonitrile (L. W. Deady et al, Aust. J. Chem., 35, 2025 (1982)) is reduced catalytically according to the procedure of D. E. Beattie et al for the preparation of 2-amino-3-aminomethyl pyridine (J. Med. Chem, 20, 718, (1977)) to give the title compound.

Sources & evidence

ORD record
ord-f67ab67e7cb24d1b84cf9f3d9c7319c0
Source dataset
uspto-grants-1996_06
Patent number
US05527819

Reaction notes

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