HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 5-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrile | HCID 22401514 | — |
| Product | Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate | HCID 135761968 | — |
Reaction Steps
5-Chloro-3-phenylsulfonylindole-2-carbonitrile is allowed to react with ethanol saturated with hydrogen chloride at 0°-10° C. for 7 days. Evaporation to dryness affords the title compound as a hydrochloride salt. The title compound is obtained as a free base by adding the reaction mixture to an ice cold solution of excess potassium carbonate and extracting the product with chloroform.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527819 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-b5ca2beacb904c069c533ceac9550f73 |
| Source note | uspto-grants-1996_06 |