Sodium Hydroxide → Sodium 2-oxopyrrolidine-5,5-dicarboxylate

HRID 260504Notes

Reaction equation

HRID 260504 reaction equation
[OH-].[Na+:2].[O:3]=[C:4]1[CH2:8][CH2:7][C:6]([C:14]([O:16]CC)=[O:15])([C:9]([O:11]CC)=[O:10])[NH:5]1>C(O)C>[O:3]=[C:4]1[CH2:8][CH2:7][C:6]([C:9]([O-:11])=[O:10])([C:14]([O-:16])=[O:15])[NH:5]1.[Na+:2].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19045188Diethyl 2-oxopyrrolidine-5,5-dicarboxylate

Product 1

HCID 14623903Sodium 2-oxopyrrolidine-5,5-dicarboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2(c) 8.74 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 1.0 g of diethyl 2-oxopyrrolidine-5,5-dicarboxylate (prepared as described above) in 10 ml of ethanol, and the mixture was stirred at room temperature for 3 days. At the end of this time, the solvent was removed by distillation under reduced pressure, and the residual crystals were washed with acetone and dried to give 950 mg of sodium 2-oxopyrrolidine-5,5-dicarboxylate as a colorless powder.

Workup

  1. customAt the end of this time, the solvent was removed by distillation under reduced pressure
  2. washthe residual crystals were washed with acetone
  3. customdried

Sources & evidence

ORD record
ord-cca070643dfc444198c4715b0ee83bd8
Source dataset
uspto-grants-1996_06
Patent number
US05527905

Reaction notes

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