Acetic Anhydride → HCID 22401670, compound

Participants

Reaction Conditions

Reaction Steps

In 20 ml of pyridine was dissolved 2.00 g (8.96 mmol) of Compound 13 prepared in Example 10, and 1.23 ml (13.0 mmol) of acetic anhydride was added to the solution, followed by stirring at 50° C. for 6 hours. After evaporation of the solvent, the residue was subjected to partition between chloroform and water. The chloroform layer was washed with a dilute aqueous solution of hydrochloric acid and water, and concentrated to dryness under reduced pressure. The residue was recrystallized from chloroform/ethanol to give 1.46 g (62%) of Compound 20 in pure form.

Provenance & Evidence