HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methylthiazole → 2-(2,3-Dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Reactant | 2-Bromo-1-(thiophen-2-yl)ethan-1-one | HCID 2776372 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(2,3-Dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide | HCID 22401741 | — |
Reaction Steps
A mixture of 51 parts of 2-bromo-1-(2-thienyl)ethanone, 28.5 parts of 5-methyl-2-thiazolamine and 240 parts of acetonitrile was stirred for 1 hour while heating on a water-bath. After cooling, the precipitate was filtered off, washed with ethanol and dried in vacuo, yielding 54 parts of 2-(2,3-dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide; mp. 207.5°-208° C (interm. 56).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527915 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-f21da8212cc340c0b8a25b691cce9bce |
| Source note | uspto-grants-1996_06 |