Potassium Hydroxide → HCID 22401755, compound

HRID 260545Notes

Reaction equation

HRID 260545 reaction equation
[OH-].[K+:2].[CH2:3]([C:7]1[N:8]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[S:32]([NH:35][C:36]([NH:38][CH2:39][CH2:40][CH3:41])=[O:37])(=[O:34])=[O:33])=[CH:22][CH:21]=2)[C:9]([C:14]([O:16]CC)=[O:15])=[C:10]([S:12][CH3:13])[N:11]=1)[CH2:4][CH2:5][CH3:6]>C(O)C>[K+:2].[K+:2].[CH2:3]([C:7]1[N:8]([CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[S:32]([NH:35][C:36]([NH:38][CH2:39][CH2:40][CH3:41])=[O:37])(=[O:34])=[O:33])=[CH:24][CH:25]=2)[C:9]([C:14]([O-:16])=[O:15])=[C:10]([S:12][CH3:13])[N:11]=1)[CH2:4][CH2:5][CH3:6].[CH2:3]([C:7]1[N:8]([CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[S:32]([NH:35][C:36]([NH:38][CH2:39][CH2:40][CH3:41])=[O:37])(=[O:34])=[O:33])=[CH:24][CH:25]=2)[C:9]([C:14]([O-:16])=[O:15])=[C:10]([S:12][CH3:13])[N:11]=1)[CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 10393298HCID 10393298, compound

Product 1

HCID 22401755HCID 22401755, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.3 ml of a 6N solution of potassium hydroxide were added at 0° C. to a solution of 2 g of the product of Stage H in 40 ml of ethanol and the reaction medium was allowed to return to ambient temperature. After. 72 hours, the precipitate was separated and washed with 4 ml of ethanol, then with 4 ml of ethyl acetate to obtain after drying, 2.04 g of the desired product melting at >260° C.

Workup

  1. customto return to ambient temperature
  2. custom72 hours, the precipitate was separated
  3. washwashed with 4 ml of ethanol
  4. customwith 4 ml of ethyl acetate to obtain
  5. customafter drying

Sources & evidence

ORD record
ord-2abcd7d0a9dd410b919cef161ea7a3c2
Source dataset
uspto-grants-1996_06
Patent number
US05527919

Reaction notes

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