HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Carbethoxyphenyl 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylmethyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethylparaben | HCID 8434 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-(Bromomethyl)-1,1,4,4-Tetramethyl-1,2,3,4-Tetrahydronaphthalene | HCID 2735597 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Carbethoxyphenyl 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylmethyl ether | HCID 14850591 | 50.8% |
Reaction Steps
10 g (36 mmol) of 2-bromomethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene, 6 g (36 mmol) of ethyl 4-hydroxybenzoate and 7.2 g (52 mmol) of anhydrous potassium carbonate in 60 ml of dimethylformamide were refluxed for 5.25 h. The mixture was then poured into water and extracted several times with ether, and the organic phase was washed with water, dried over Na2SO4 and concentrated. Recrystallization from methanol resulted in 6.7 g of the title compound of melting point 109°-11° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527945 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-f75bbc7f4d8a4c7187ebdf2b499a8401 |
| Source note | uspto-grants-1996_06 |