Hydrochloric Acid → HCID 54474777, compound

Participants

Reaction Steps

To a mixture of lithium aluminum hydride (0.06 g, 1.58 mmol) in diethyl ether (5 ml) is added dropwise acetoxymethyldimethyl-3-fluorobenzylsilane (0.38 g, 1.58 mmol) in diethyl ether (2 ml). The mixture is then allowed to react for 0.5 hours at room temperature, treated with ethylacetate (2 ml), hydrolyzed with 1N HCl (6.5 ml), and poured into water (20 ml) and diethyl ether (10 ml). The organic layer is washed with water, brine, dried over MgSO4 and the solvent removed in vacuo. Chromatography (silica gel, hexane/ether-60/40 affords the title compound (0.23 g, 73% yield).

Provenance & Evidence