Silane, chloro(chloromethyl)dimethyl- → Chloromethyl-(2,4-difluorobenzyl)dimethylsilane

HRID 260643Notes

Reaction equation

HRID 260643 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[CH2:4][Mg]Cl.Cl[Si:13]([CH2:16][Cl:17])([CH3:15])[CH3:14]>>[Cl:17][CH2:16][Si:13]([CH2:4][C:3]1[CH:7]=[CH:8][C:9]([F:11])=[CH:10][C:2]=1[F:1])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 74393Silane, chloro(chloromethyl)dimethyl-HCID 178505761HCID 178505761, compound

Product 1

HCID 22399702Chloromethyl-(2,4-difluorobenzyl)dimethylsilaneYield 95%

Procedure

The title compound is prepared in 95% yield from 2,4-difluorobenzylmagnesium chloride and chlorochloromethyldimethylsilane by the method described in Example 5, Step A.

Sources & evidence

ORD record
ord-f59ceee6259247469d1327667b400278
Source dataset
uspto-grants-1996_06
Patent number
US05529988

Reaction notes

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