HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenepropanoic acid → tert-Butyl(dimethyl)silyl 3-phenylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenepropanoic acid | HCID 107 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-Butyl(dimethyl)silyl 3-phenylpropanoate | HCID 554838 | — |
Reaction Steps
Dissolve 3-phenylpropionic acid (1.5 g, 10 mmol) in dimethylformamide (5 mL) and add t-butyldimethylsilyl chloride (7.5 g, 50 mmol) and imidazole (6.8 g, 0.1 mol). Stir for 48 hours at room temperature, pour into ethyl ether and water and separate the organic phase. Dry (MgSO4) and evaporate the solvent in vacuo to give 3-phenylpropionic acid, t-butyldimethylsilyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05529997 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-e1e940715b1748ba88edcfbf2c895295 |
| Source note | uspto-grants-1996_06 |