Potassium sodium tartarate → 4-[2-(5-Methoxy-1H-inden-3-yl)ethyl]-1-(naphth-1-yl)piperazine

HRID 260664Notes

Reaction equation

HRID 260664 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[CH2:14][CH:13]=[C:12]2[CH2:18][C:19]([N:21]1[CH2:26][CH2:25][N:24]([C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=[CH:29][CH:28]=2)[CH2:23][CH2:22]1)=O.C(C(C(C([O-])=O)O)O)([O-])=O.[K+].[Na+]>CCOCC>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[CH2:14][CH:13]=[C:12]2[CH2:18][CH2:19][N:21]1[CH2:22][CH2:23][N:24]([C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=[CH:29][CH:28]=2)[CH2:25][CH2:26]1

Participants

5

Reactant 3

HCID 9855836Potassium sodium tartarateHCID 21226445Aluminium lithium hydrideHCID 224002654-[(5-Methoxy-1H-inden-3-yl)acetyl]-1-(naphth-1-yl)piperazine

Product 1

HCID 224002684-[2-(5-Methoxy-1H-inden-3-yl)ethyl]-1-(naphth-1-yl)piperazine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

0.76 g (0.02 mol) of lithium aluminum hydride are placed under an argon atmosphere in a 500 ml round-bottomed flask and covered with diethyl ether. A Soxhlet extractor containing 2.0 g (0.005 mol) of 4-[(5-methoxy-1H-inden-3-yl)acetyl]-1-(naphth-1-yl)piperazine is placed on top of the flask, and the mixture is reacted with refluxing of the ether for 30 h. The reaction mixture is treated with 1.6 ml of 10% aqueous sodium potassium tartrate solution and filtered. The solid is washed with diethyl ether and then with tetrahydrofuran, and the filtrate is evaporated under reduced pressure.

Workup

  1. customthe mixture is reacted
  2. filtrationfiltered
  3. washThe solid is washed with diethyl ether
  4. customwith tetrahydrofuran, and the filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-a204815f12ee4cc2a4dad58cc6296111
Source dataset
uspto-grants-1996_06
Patent number
US05530002

Reaction notes

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