HCID 10360296, compound → HCID 53784493, compound

HRID 260740Notes

Reaction equation

HRID 260740 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[C:7](/[C:10](/[CH3:16])=[CH:11]/[C:12]([O:14][CH3:15])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].[H][H].CCCCCC.C(OCC)(=O)C>CO.[Pt]=O>[CH2:1]([C:5]1[N:6]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[C:7]([CH:10]([CH3:16])[CH2:11][C:12]([O:14][CH3:15])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 3

HCID 10360296HCID 10360296, compoundHCID 21226206Ethyl acetate hexaneHCID 178418361HCID 178418361, compound

Product 1

HCID 53784493HCID 53784493, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A mixture of methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate (165 mg, 0.476 mmol) in methanol (10 mL) and platinum oxide (20 mg) was shaken under one atmosphere of hydrogen for 3 hours. TLC on silica gel with 6:4 hexane/ethyl acetate showed a homogenous spot with an Rf 0.54. The catalyst was filtered, and the filtrate was concentrated to 154 mg (93%) of the title compound.

Workup

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate was concentrated to 154 mg (93%) of the title compound

Sources & evidence

ORD record
ord-b92cc7aa4e074c0186e1da90618660ae
Source dataset
uspto-grants-1996_06
Patent number
US05530017

Reaction notes

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