HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazole → methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazole | HCID 19351554 | — |
| Reactant | Diethyl [1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]malonate | HCID 54435009 | — |
| Solvent | Hydrochloride methanol | HCID 21893726 | — |
| Product | methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride | HCID 22400438 | — |
Reaction Steps
Diethyl [1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]malonate was converted to 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetic acid by the method described in Example 15. The methyl ester was prepared in methanol/hydrochloric acid to give methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride; mp 158°-159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05530017 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-ae77781c34434ed28415577bc0001136 |
| Source note | uspto-grants-1996_06 |