Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 260754Generated: October 27, 2026

Diethyl 2-benzylpropanedioate → 3-[2-n-Butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-benzylpropanoic Acid

https://huagongshe.com/reaction/260754

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl 2-benzylpropanedioateHCID 69090—
ReactantMethyl 4-[(2-butyl-5-formyl-1H-imidazol-1-YL)methyl]benzoateHCID 10334966—
Product3-[2-n-Butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-benzylpropanoic AcidHCID 54294497—

Reaction Steps

The title compound was prepared following the procedure of Example 21 using 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde and diethyl benzylmalonate; mp 120°-124° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05530017
Source datasetuspto-grants-1996_06
ORD IDord-6acf0f8f116041b38b5eca6ad0a8d3e4
Source noteuspto-grants-1996_06