HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Acetyl-3-[2-acetoxy-4-(1,1-dimethylheptyl)phenyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]piperidine | HCID 15571558 | — |
| Product | 1-Acetyl-3-[2-acetoxy-4-(1,1-dimethylheptyl)phenyl]piperidine | HCID 20499779 | — |
Reaction Steps
To a solution of 2.0 g. of 3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]piperidine in 20 ml. of pyridine at 10° C. is added 20 ml. of acetic anhydride and the mixture stirred under nitrogen for 18 hours. It is then poured onto ice/water and acidified with dilute hydrochloric acid. The product is isolated by extraction with ethyl acetate (2 × 100 ml.). The combined extracts are washed with brine, dried (MgSO4) and evaporated to give the product as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04147872 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-38894303669d459dbe1bbe5890958843 |
| Source note | uspto-grants-1979_04 |