HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-nitrobenzoic acid → 3-Amino-2-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-nitrobenzoic acid | HCID 16096 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-2-methylbenzoic acid | HCID 2733699 | — |
Reaction Steps
A solution of 2-methyl-3-nitrobenzoic acid (mp. 182°-184° C., 22 g, 0.12 mol) in 400 mL of methanol was hydrogenated over platinum oxide (100 mg) for 45 minutes at 55 pounds per square inch (psi), whereupon the catalyst was filtered off through a bed of Celite® (50 g), and the solvent evaporated under reduced pressure to give 3-amino-2-methylbenzoic acid (mp. 178°-181° C.) in quantitative yield (18.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05530028 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-14b48dccef744d71888c9ba77025118e |
| Source note | uspto-grants-1996_06 |