Ethyl 4-[3-[8-(4-isobutylphenyl)undecanoyl]1-indolyl]butyrate → 4-[3-[5-(4-Isobutylphenyl)valeryl]-1-indolyl]butyric acid

HRID 260845Notes

Reaction equation

HRID 260845 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]([C:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]([CH2:26][CH2:27][CH2:28][C:29]([O:31]CC)=[O:30])[CH:18]=2)=[O:16])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].C(C1C=CC(C(CCC)CCCCCCC(C2C3C(=CC=CC=3)N(CCCC(OCC)=O)C=2)=O)=CC=1)C(C)C>>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]([C:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]([CH2:26][CH2:27][CH2:28][C:29]([OH:31])=[O:30])[CH:18]=2)=[O:16])=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 22400460Ethyl 4-[3-[8-(4-isobutylphenyl)undecanoyl]1-indolyl]butyrateHCID 22400526Ethyl 4-[3-[5-(4-isobutylphenyl)valeryl]-1-indolyl]butyrate

Product 1

HCID 224005484-[3-[5-(4-Isobutylphenyl)valeryl]-1-indolyl]butyric acid

Procedure

The procedure of Ex. 16 was repeated except that ethyl 4-[3-[5-(4-isobutylphenyl)valeryl]-1-indolyl]butyrate obtained in Ex. 23 was used in place of ethyl 4-[3-[8-(4-isobutylphenyl)undecanoyl]-1-indolyl]butyrate to give 4-[3-[5-(4-isobutylphenyl)valeryl]-1-indolyl]butyric acid.

Workup

  1. customobtained in Ex

Sources & evidence

ORD record
ord-5ef531307d174fcb8964617c5e251686
Source dataset
uspto-grants-1996_06
Patent number
US05530019

Reaction notes

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