4-[3-(3,7-Dimethyl-6-octenoyl)-1-indolyl]butyric acid → 4-[3-(3,7-Dimethyloctanoyl)-1-indolyl]butyric acid

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Reaction Steps

A mixture of 4-[3-(3,7-dimethyl-6-octenoyl)-1-indolyl]butyric acid (267 mg) obtained in Ex. 30 and 10% palladium carbon (80 mg) in methanol was stirred at room temperature for 3 hours under a hydrogen atmosphere at 3 atm. The catalyst was removed and the solvent was evaporated. The residue was chromatographed on a silica gel column (3-10% methanol in chloroform as an eluent) to give 4-[3-(3,7-dimethyloctanoyl)-1-indolyl]butyric acid (142 mg) as an oil.

Provenance & Evidence