Water → HCID 10613884, compound

Participants

Reaction Steps

To lithium aluminum hydride (1.76 g, 46.3 mmol) in THF (43 ml), 1-[N-(1-Azabicyclo[3.3.0 ]octan-5-yl )methyl-N-formylamino]-4-methoxynaphthalene (3.00 g, 9.26 mmol) in THF (15 ml) was added dropwise at room temperature. After refluxed for 1 hour, the reaction mixture was cooled and chilled water was added dropwise. Formed solids were removed by filtration and the filtrate was concentrated in vacuo and purified by chromatography to afford the desired compound (1.80 g, 62.7%), as a pale yellow liquid.

Provenance & Evidence