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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 260919Generated: November 2, 2026

Formamide, N-1-naphthalenyl- → 1-{N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-N-formylamino}naphthalene

https://huagongshe.com/reaction/260919

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormamide, N-1-naphthalenyl-HCID 96004—
Reactant5-(2-Chloroethyl)-1-azabicyclo[3.3.0]octaneHCID 10702365—
Product1-{N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-N-formylamino}naphthaleneHCID 10781138—

Reaction Steps

The procedures described in Example 2 were repeated except that N-formyl-1-naphthylamine (1.90 g, 11.1 mmol ) and 5-(2-chloroethyl)-1-azabicyclo[3.3.0]octane (hydrochloride, 2.57 g, 12.2 mmol ) were employed In this case, the desired compound was obtained as a colorless liquid (1.80 g, 52.6%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05530138
Source datasetuspto-grants-1996_06
ORD IDord-246eb5d1fb184c0682be54ddb7af4258
Source noteuspto-grants-1996_06