HuagongsheHuagongshe Chemistry Print Report · For research reference only
2'-Phenylformanilide → N-(1-Azabicyclo[3.3.0]octan-5-yl)methyl-N-formyl-2-phenylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2'-Phenylformanilide | HCID 219948 | — |
| Reactant | 7a-(chloromethyl)-hexahydro-1H-pyrrolizine | HCID 10773251 | — |
| Product | N-(1-Azabicyclo[3.3.0]octan-5-yl)methyl-N-formyl-2-phenylaniline | HCID 10781977 | — |
Reaction Steps
The procedures described in Example 2 were repeated except that 2-formylamino-1,1'-biphenyl (286 mg, 1.45 mmol ) and 5-chloromethyl-1-azabicyclo[3.3.0]octane (hydrochloride, 300 mg, 1.53 mmol) were employed. In this case, the desired compound was obtained as pale yellow solids (452 mg, 97.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05530138 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-d4d371276d054992849363126a6663fc |
| Source note | uspto-grants-1996_06 |