7a-(chloromethyl)-hexahydro-1H-pyrrolizine → N-(1-Azabicyclo[3.3.0]octan-5-yl)methyl-N-formyl-3-phenylaniline

Participants

Reaction Steps

The procedures described in Example 2 were repeated except that 3-formylamino-1,1'-biphenyl (286 mg, 1.45 mmol) and 5-chloromethyl-1-azabicyclo[3.3.0]octane (hydrochloride, 800 mg, 1.53 mmol) were employed. In this case, the desired compound was obtained as pale yellow solids (385 mg, 82.7%).

Provenance & Evidence