反应详情

2-Fluorobenzonitrile (1.00 g, 8.26 mmol) and 2-(1-azabicyclo[3.3.0]octan-5-yl)ethylamine (3.15 g, 20.4 mmol) were added into anhydrous pyridine (10.0 ml) to react the mixture in a sealed tube for 10.5 hours at 180° C. After addition of water subsequent to concentration in vacuo, the reaction mixture was extracted by ethyl acetate, dried over anhydrous sodium sulfate, concentrated in vacuo, and refined by column chromatography to afford the desired compound (2.02 g, 95.8%), as a colorless liquid.

1. customto react the mixture in a sealed tube for 10.5 hours at 180° C
2. concentrationto concentration in vacuo
3. extractionthe reaction mixture was extracted by ethyl acetate
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo