HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzonitrile → 4-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethylamino]-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | 2-(Hexahydro-1H-pyrrolizin-7a-yl)ethanamine | HCID 10796977 | — |
| Product | 4-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethylamino]-benzonitrile | HCID 10658697 | — |
Reaction Steps
The procedures described in Example 1 were repeated except that 4-fluorobenzonitrile (1.00 g, 8.26 mmol ) and 2-(1-azabicyclo[3.3.0]octan-5-yl)ethylamine (3.15 g, 20.4 mmol) were employed. In this case, the desired compound was obtained as a colorless liquid (2.02 g, 99.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05530138 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-f145bbc30c9d4e319a8f9c18926c3003 |
| Source note | uspto-grants-1996_06 |