HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluoronitrobenzene → N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-4-fluoro-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Reactant | 2-(Hexahydro-1H-pyrrolizin-7a-yl)ethanamine | HCID 10796977 | — |
| Product | N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-4-fluoro-2-nitroaniline | HCID 10803648 | — |
Reaction Steps
The procedures described in Example 1 were repeated except that 2,5-difluoronitrobenzene (1.00 g, 6.29 mmol) and 5-(2-aminoethyl)-1-azabicyclo[3.3.0]octane (2.42 g, 15.7 mmol) were employed. In this case, the desired compound was obtained as a colorless liquid (2.00 g, quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05530138 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-56df4a4bfc254375bae5d7b63d7b98ce |
| Source note | uspto-grants-1996_06 |