HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)ethyl]-2-nitroaniline → SK 946
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)ethyl]-2-nitroaniline | HCID 178115 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | SK 946 | HCID 6442273 | 98.8% |
Reaction Steps
A mixture of N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-2-nitroaniline (200 mg, 728 μmol) obtained by Example 23 in ethanol (10 ml) and fumaric acid (84.2 mg, 725 μmol) in ethanol (10 ml) was concentrated until its volume becomes 5 ml and left to stand to afford the desired salt (265 mg, 98.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05530138 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-e1fc883f5beb4c57968f6437cb34bc5c |
| Source note | uspto-grants-1996_06 |