Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 4-(2,4-Difluorophenyl)-1,1,1-trifluoro-4-hydroxy-3-buten-2-one | HCID 69934778 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178505511 | HCID 178505511 | 94% |
Reaction Steps
At 24° C., 15.0 g (0.06 mole) of the product of step A was dissolved in 50 mL glacial acetic acid and treated with 2 mL (0.064 mole) anhydrous hydrazine, added over a period of 5 minutes. The reaction was heated to 95° C. for 30 minutes. The reaction was cooled and poured into 300 mL ice water. The slurry was filtered and the cake washed with water and air dried to give 13.86 g (94%) of 5-(2,4-difluorophenyl)-3-(trifluoromethyl)-1H-pyrazole as a white solid, mp 157°-158° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05530126 |
|---|
| Source dataset | uspto-grants-1996_06 |
|---|
| ORD ID | ord-3529431ae3f54028b402e174bf60e037 |
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| Source note | uspto-grants-1996_06 |
|---|
