Ammonia → 3,5-Dichloro-2,4-difluorobenzamide

HRID 260988Notes

Reaction equation

HRID 260988 reaction equation
[NH3:1].[Cl:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([Cl:13])[C:11]=1[F:12])[C:6](F)=[O:7]>O>[Cl:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([Cl:13])[C:11]=1[F:12])[C:6]([NH2:1])=[O:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54637643,5-Dichloro-2,4-difluorobenzoyl fluoride

Product 1

HCID 135650273,5-Dichloro-2,4-difluorobenzamideYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

620 ml of concentrated aqueous ammonia solution and 600 ml of water are initially introduced, 458 g (2 moles) of 3,5-dichloro-2,4-difluorobenzoyl fluoride are added dropwise at 40°-50°, and then the mixture is stirred at 50° for 30 minutes. The precipitate is filtered off with suction, washed with water and dried. 408 g (90% of theory) of 3,5-dichloro-2,4-difluorobenzamide of melting point 163°-164° are obtained.

Workup

  1. filtrationThe precipitate is filtered off with suction
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-7b9f2188ef374ea399eb4f01eb358282
Source dataset
uspto-grants-1996_06
Patent number
US05530158

Reaction notes

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