HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 26099Generated: October 29, 2026
Trifluoroacetic acid → 7beta-Phenoxyacetamido-3-methoxy-3-cephem-4-carboxylic acid
https://huagongshe.com/reaction/26099
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | Diphenylmethyl (6R-trans)-3-methoxy-8-oxo-7-(phenoxyacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate | HCID 6453042 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7beta-Phenoxyacetamido-3-methoxy-3-cephem-4-carboxylic acid | HCID 12784142 | — |
Reaction Steps
0.87 ml of anisole is added to a solution of 2.0 g (3.78 mmols) of 7β-phenoxyacetamido-3-methoxy-ceph-3-em-4-carboxylic acid diphenylmethyl ester in 5 ml of methylene chloride and the mixture is cooled to 0° C. and left to stand for 1 hour after adding 1.2 ml of trifluoroacetic acid. The reaction mixture is concentrated in vacuo and the residue is crystallised from acetone/ether. 7β-Phenoxyacetamido-3-methoxy-ceph-3-em-4-carboxylic acid of melting point 170° C. (decomposition) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04147864 |
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| Source dataset | uspto-grants-1979_04 |
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| ORD ID | ord-5dba2cb20e32486c845a80daf642815b |
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| Source note | uspto-grants-1979_04 |
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