Indole → HCID 9859793, compound

Participants

Reaction Steps

A mixture of indole (4.16 g; 35.53 mmol), methyl 2-bromobenzoate (2.64 g; 35.53 mmol), potassium carbonate (5.50 g) and CuO (2.0 g) in 40 mL of DMF was refiuxed uncler an argon atmosphere for 3.5 hrs. The crude material obtained upon extraction into ethyl acetate and removal of the solvent was purified on a silica gel column (10% ethyl acetate/hexane) to obtain 4.20 g (47%) of methyl 2-(1-indolyl)benzoate, 1H NMR (CDCl3): δ 3.45 (s, 3H); 6.43 (d, 1H); 6.99-7.20 (m, 4H); 7.35-7.42 (m, 2H); 7.60 (m, 2H); 7.88 (d, 1H).

Provenance & Evidence