2-Aminopyridine → N-Pyridin-2-yl-N'-1,2,3-thiadiazol-5-ylurea

HRID 261001Notes

Reaction equation

HRID 261001 reaction equation
O([C:8]([NH:10][C:11]1[S:15][N:14]=[N:13][CH:12]=1)=[O:9])C1C=CC=CC=1.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>CC(C)=O>[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[NH:16][C:8]([NH:10][C:11]1[S:15][N:14]=[N:13][CH:12]=1)=[O:9]

Participants

4

Reactant 2

HCID 104392-AminopyridineHCID 320280MLS003107275

Product 1

HCID 20233425N-Pyridin-2-yl-N'-1,2,3-thiadiazol-5-ylurea

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

16.5 g (0.075 mol) 5-phenoxycarbonylamino-1,2,3-thiadiazole are suspended in 150 ml acetone and reacted with 9.4 g (0.1 mol) of 2-aminopyridine. The reaction mass is then refluxed for 3 hours. After cooling to room temperature the formed light brown crystals are removed by suction and dried. They are then recrystallized from ethanol. There is thus obtained the above noted title compound (compound No. 1).

Workup

  1. temperatureThe reaction mass is then refluxed for 3 hours
  2. customare removed by suction
  3. customdried
  4. customThey are then recrystallized from ethanol

Sources & evidence

ORD record
ord-11da2a4b811c476cb0d6af7681fc096f
Source dataset
uspto-grants-1979_08
Patent number
US04163658

Reaction notes

Loading…