HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 261015Generated: October 26, 2026
Dimethylformamide → HCID 178476927, compound
https://huagongshe.com/reaction/261015
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Ethyl phosphorochloridite | HCID 68530 | — |
| Reactant | 1,5-Diazabicyclo(4.3.0)non-5-ene | HCID 76349 | — |
| Reactant | HCID 178513083 | HCID 178513083 | — |
| Product | HCID 178476927 | HCID 178476927 | — |
Reaction Steps
A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (300 ml.) is cooled to 10° C. and treated with diethyl chlorophosphite (2.9 ml., 0.02 mole). The reaction is stirred at 25° C. for 3 hours, filtered and treated with ice water (300 ml.) to give diethyl N-[(3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 230° C. after recrystallization from ethanol-water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04163781 |
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| Source dataset | uspto-grants-1979_08 |
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| ORD ID | ord-960ab3d9ab704cd8b07c05ab4008cd5d |
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| Source note | uspto-grants-1979_08 |
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