2-Thiophenecarboxaldehyde → HCID 3592891, compound

HRID 261019Notes

Reaction equation

HRID 261019 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.Cl.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][NH2:17])=[CH:12][CH:11]=1.C([O-])(=O)C.[Na+]>C(O)C>[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][N:17]=[CH:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 73642-ThiophenecarboxaldehydeHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 517045Sodium Acetate

Product 1

HCID 3592891HCID 3592891, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

14.8 g of 2-thiophenecarbaldehyde was added to a mixture of 25.2 g of p-chlorophenylhydrazine hydrochloride and 33.6 g of sodium acetate in 400 ml of 50% aqueous ethyl alcohol. The mixture was heated on a water bath for 30 minutes. After cooling, the precipitated solid was collected and crystallized from ethyl alcohol to give 1, as yellow needles, mp 137° C.

Workup

  1. temperatureThe mixture was heated on a water bath for 30 minutes
  2. temperatureAfter cooling
  3. customthe precipitated solid was collected
  4. customcrystallized from ethyl alcohol
  5. customto give 1

Sources & evidence

ORD record
ord-0b99c87c58fa438185a43af63d515614
Source dataset
uspto-grants-1979_08
Patent number
US04163793

Reaction notes

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