HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 178419104, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Ethyl 2-methylpropanimidate--hydrogen chloride (1/1) | HCID 12816252 | — |
| Solvent | Trimethylamine | HCID 1146 | — |
| Product | HCID 178419104 | HCID 178419104 | — |
Reaction Steps
The method according to claim 1 wherein ethyl isobutyrimidate hydrochloride is neutralized by trimethylamine dissolved in toluene, the free ethyl isobutyrimidate is freed from water by azeotropic distillation; then the dry ethyl isobutyrimidate in toluene is reacted with an excess of diketene dissolved in toluene in the presence of trimethylamine and the resulting organic solution is treated with gaseous ammonia, in molar equivalent amounts and subsequent azeotropic removal of water to form 2-isopropyl-4-methyl-6-hydroxypyrimidine which is dried and recovered from said organic solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04163848 |
| Source dataset | uspto-grants-1979_08 |
| ORD ID | ord-d986d003f8234d2b8dbbaac6d7f06df9 |
| Source note | uspto-grants-1979_08 |